Well know you can with dotMailer's nifty Email Client Analysis tool.
Currently available to Enterprise clients, within your campaign reports is a little 'magnifying glass' icon to the right of the 'Unique Opens' link.
Click on the magnifying glass to be taken to the Email Client Analysis Tool where dotMailer will show you a full breakdown of the email clients which handled your campaign.
This could be Outlook, an iPhone, a Blackberry or an Android. How many of your recipients use their email client in Chrome or Safari? Or just what percentage of your recipients actually use Lotus Notes? The answers are only a click away!
This data is gold dust when it comes to optimising the design of your emails to render in your most commonly used email clients. Use it wisely.